Zopiclone works by enhancing the effect of GABA (an inhibitory neurotransmitter) at GABA-A receptors, helping reduce the time to fall asleep and decrease night-time awakenings.
Usage and dosage (general guidance from standard references)
Zopisign/zopiclone is indicated for short-term treatment of insomnia in adults when sleep disturbance is severe, disabling, or causing significant distress. It is not intended for long-term use.​
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Adults: Many official sources (e.g., UK BNF and various product monographs) recommend a usual dose of 7.5 mg taken once daily at bedtime. A 10 mg strength exists and is marketed in some regions, but the maximum recommended dose in many guidelines is 7.5 mg because higher doses increase the risk of next-day impairment (drowsiness, reduced alertness, driving risk). Always follow the dose prescribed by your doctor.​
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Elderly, debilitated patients, or those with liver/kidney/respiratory impairment: Start lower (commonly 3.75 mg).
How to take: Swallow the tablet whole with water immediately before going to bed. Take on an empty stomach if possible (food, especially high-fat meals, can delay onset). Ensure you can stay in bed for 7–8 hours after the dose. Do not take a second dose the same night.
Duration: Keep as short as possible — typically a few days to 2 weeks; maximum usually 4 weeks (including any gradual dose reduction/taper). Longer use requires medical re-evaluation because of dependence and tolerance risk.​
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Important precautions
Avoid alcohol and other sedatives/CNS depressants (increased sedation and respiratory depression risk).
Do not drive or operate machinery until you know how the medicine affects you (next-day drowsiness is possible).

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Do not stop suddenly after regular use — taper under medical advice to reduce withdrawal symptoms.
Contraindications (typical): hypersensitivity to zopiclone, severe respiratory insufficiency, severe sleep apnoea, myasthenia gravis, severe hepatic impairment, and generally not for use under 18 years.
Common side effects: bitter/metallic taste, drowsiness, dry mouth, dizziness. Less common but serious: complex sleep behaviours (e.g., sleep-driving), memory problems, mood/behaviour changes, allergic reactions — seek medical help if these occur.

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